Enzyme Engineering
Design, test, and iterate on your target sequence, optimizing for multiple properties
Optimize
Improve thermostability, activity, and solubility
- Test tens of thousands of variants in parallel through multiple rounds of evolution
- Integrate experimental results into each round of machine learning, fine-tuning our AI for higher scoring in your property of interest
Design
Enzymes targeted to your substrate
- Scaffold an existing motif or diversify the sequence/structure of an existing binder
- Generate de-novo protein structures targeted to your substrate
- Optimize for kcat/km/binding affinity to a substrate
- Generate sequences given Enzyme Commission annotations or starting sequences
Molecular Dynamics
Apply physics-based methods for free energy calculations
- Run molecular dynamics simulations to evaluate protein-ligand complex dynamic trajectories
- Perform large scale protein-ligand docking
- Predict system stability over time
Structural modeling
Large scale structure prediction of proteins and protein-ligand complexes
- Build a structure for your enzyme, incorporating templates
- Model protein-ligand complexes given a sequence and ligands/cofactors
